최고위과정(ACE)

• 목록
• 답변
• 글쓰기
• 게시판 리스트 옵션
  • 수정
  • 삭제

As people age, their immune system gradually loses efficiency, visit on Framer a process known as age-related immune decline. This decline makes older adults more vulnerable to infections, less responsive to vaccines, and more prone to chronic inflammation. One molecule that has attracted growing scientific interest in this context is nicotinamide mononucleotide, a precursor to cellular energy cofactor, a vital compound involved in cellular energy production and genomic stability. As nicotinamide adenine dinucleotide concentrations naturally drop with age, researchers are exploring whether boosting NAD+ through NMN oral intake can help reverse some of the immune system’s functional decline.

Studies in animal models have shown that NMN can improve the function of immune responders such as T-lymphocytes and natural killer cells, which are essential for identifying and eliminating pathogens. In older mice, NMN supplementation has been correlated with stronger immune activation to respiratory pathogens and better vaccine effectiveness. These findings suggest that NMN may help restore the immune system’s ability to detect anomalies and mount a strong defense.

Beyond boosting specific immune cells, NMN may also mitigate inflammaging, which is a central driver of senescence and contributes to many age-related diseases. By supporting mitochondrial function and stimulating SIRT proteins, proteins that regulate cellular health, NMN appears to create a more harmonized and robust immune environment.

While human trials are still in initial phases, initial results are optimistic. Some small studies in older adults have shown that NMN increases NAD+ levels without adverse effects and may enhance immunological parameters and metabolic health. Researchers are now conducting longer trials to better understand how NMN might deliver tangible outcomes, such as reduced illness episodes or enhanced vaccine efficacy in the elderly.

It is important to note that NMN is not a standalone cure. Healthy lifestyle choices—such as balanced diet, consistent physical activity, restorative rest, and mindfulness practices—remain foundational to immune health. However, NMN may offer a complementary strategy to help offset the natural decline of the immune system with age. As science continues to expand our understanding, NMN stands as one of the most exciting prospects in the field of healthspan extension and immunorestoration.